Effects of metal ions on the utilization of glucose and on the influence of insulin on it by the isolated rat diaphragm.
نویسنده
چکیده
Kornberg, A. (1950). J. biol. Chem. 182, 779. Layne, D. S. & Marrian, G. F. (1958). Biochem. J. 70, 244. Loke, K. H. (1958). Ph.D. Thesis: University of Edinburgh. Mitoma, C., Posner, H. S., Reitz, H. C. & Udenfriend, S. (1956). Arch. Biochem. Biophys. 61, 431. Mueller, G. C. (1955). Nature, Lond., 176, 127. Mueller, G. C. & Rumney, G. (1957). J. Amer. chem. Soc. 79, 1004. Pellerin, J. & D'Ionio, A. (1958). Canad. J. Biochem. Physiol. 36, 491. Ryan, K. J. & Engel, L. L. (1957). J. biol. Chem. 225, 103. Scrimgeour, K. G. & Huennekens, F. M. (1960). Biochem. biophys. Res. Commun. 2, 230. Tomkins, G. M., Curran, J. F. & Michael, P. J. (1958). Biochim. biophys. Acta, 28, 449. Whitely, H. R., Osborn, M. J. & Huennekens, F. M. (1958). J. Amer. chem. Soc. 80, 757.
منابع مشابه
MONOPHASIC STATE OF INSULIN SECRETION IN ISOLATED RAT ISLETS OF LANGERHANS BY K+, Ca2+ AND GLUCOSE
Isolation of rat islets of Langerhans was carried out by using collagenase and the destruction of exocrine tissue was performed through the injection of Hanks' solution into the common bile duct. The identification of the islets was done by techniques including the use of a stereomicroscope against a black background. Vital staining was done by an injection of neutral red solution through t...
متن کاملEffect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets
Objective: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level.This study was undertaken to investigateits direct effect on the islets of Langerhans. Material and Methods: Male albino Wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. The islets were incubated for 60 min in Krebs bicarbonate buffer containi...
متن کاملDifferential Metabolic Effects of Novel Cilostamide Analogs, Methyl Carbostiryl Derivatives, on Mouse and Hyperglycemic Rat
Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...
متن کاملGlucose Influence on Copper Ion-Dependent Oxidation of Low Density Lipoprotein
Background: It is well established that oxidative modification of low density lipoprotein (LDL) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. We examined the in vitro effect of glucose on native and glycated LDL oxidation using copper ion dependent oxidation system. Methods: In this study, LDL was isolated from plasma...
متن کاملCytotoxic Effect of \" Glycated Albumin-Transition Metal Ion\" on Rat Hepatocyte Suspension
Background: Combination of glycation and oxidation is associated with diabetes mellitus. The aim of this study was to clarify the effect of glycated proteins in presence of transition metal ions on production of reactive oxygen species (ROS) in rat hepatocyte suspension. Methods: Glycated albumin was prepared by incubation of bovine serum albumin with 100 mM glucose in 0.3 M phosphate buffer a...
متن کاملبررسی اثر گلوکزآمین بر فعالیت آنزیمهای گلوکوکیناز و هگزوکیناز پانکراس و ارتباط آن با ترشح انسولین از جزایر لانگرهانس موشهای صحرایی سالم و دیابتی نوع 2
Background: Glucokinase serves as a glucose sensor in pancreatic β-cells and plays a key role in glucose homeostasis and glucose-stimulated insulin secretion (GSIS). In the present study we examined the effect of glucosamine, a glucokinase inhibitor, on the pancreatic glucokinase and hexokinase activities and on insulin secretion from freshly rat pancreatic islets of Langerhans. Insulin concen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Biochemical journal
دوره 79 2 شماره
صفحات -
تاریخ انتشار 1961